Pre‐stroke chronic cerebrovascular disease is a major determinant for response to structured cognitive rehabilitation following acute ischemic strokes

Background Post Stroke Cognitive Impairment (PSCI) is seen in 40-60% of patients with ischemic strokes. Response PSCI to structured cognitive rehabilitation not clearly understood. We evaluated baseline variables that predict response an eight-week non-pharmacological intervention among mild strokes and compared the responses acute stroke without chronic cerebrovascular disease (CVD). Method 139 survivors were recruited from a tertiary hospital Singapore. All underwent group programme (Figure 1). Baseline, immediate post-intervention (Immediate-PI) 6-month post (6-month-PI) global quality life (QOL) outcomes assessed by Montreal Assessment (MoCA) Dementia-Quality Life (DemQOL). Regression analyses influence on outcomes. Result The mean age subjects 63.6 (±9.66) 64.4% males. Baseline MoCA DemQOL scores 23.30 (±3.05) 79.16 (±14.80). At Immediate-PI, more past (p = 0.033) severe white matter hyperintensities (WMH) 0.048), benefited less outcome (Table Male 0.074) WMH 0.048) QOL 2). 6-month-PI, microhemorrhages deep region 0.002) likely sustain improvement. With every experienced, experience improvement score Immediate-PI (OR 2.17, 95% CI: 0.980-4.813, p 0.056). 2.13, 1.04-4.38, 0.039). Finally, retain improvements at 6-month-PI 19.93, 1.04-384, 0.047) Conclusion Pre-stroke CVD associated worse QoL rehabilitation. Understanding factors result poor will allow clinicians better select for Future research could build these findings allocate resources at-risk groups post-stroke care, therefore reducing burden ensuring survivors.